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Ritonavir or lopinavir/ritonavir considerably enhance plasma concentrations of oxycodone in nutritious human volunteers as a consequence of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin greatly decreases plasma concentrations of oxycodone as a result of strong induction of CYP3A4.Opioids for instance oxycodone hydrochloride may well impact the hy